Munster will be without Conor Murray for their European Champions Cup clash with Saracens this weekend.

It’s a massive blow for Anthony Foley’s side, who make the trip to London for the round five pool game (1.0pm).

Keith Wood offered a very pessimistic prognosis should Murray be absent to Newstalk's Oisin Langan prior to the team announcement.

Foley has made eight changes to the side that started against Zebre last weekend.

Denis Hurley returns to partner Pat Howard in midfield. Duncan Williams comes in to make his first European start, while Keith Earls and Dave O'Callaghan are named in a European matchday squad for the first time this season.

MUNSTER v (Saracens): F Jones; A Conway, P Howard, D Hurley, S Zebo; I Keatley, D Williams; J Cronin, D Casey, BJ Botha; D Foley, P O'Connell; P O'Mahony c, T O'Donnell, CJ Stander.

Replacements: E Guinazu, J Ryan, S Archer, B Holland, D O'Callaghan, R O'Mahony, JJ Hanrahan, K Earls.

And we're off! London bound for #SarVMun #SUAF pic.twitter.com/mNOpK3udKL

— Munster Rugby (@Munsterrugby) January 16, 2015