The two metre social distancing rule for hotels, pubs and restaurants could be reduced to one metre at times when the COVID-19 transmission rate is low.
Guidelines are being reviewed to help the hospitality sector, with fears the current measures mean thousands of people will not return to work in the tourism sector.
Chief Medical Officer Dr Tony Holohan said on Monday they are examining the social distancing guidelines for the hospitality sector.
"We think we could make a further contribution, if you like, to the continued assurance of safety of both staff and customers in the hospitality sector over the course of periods of low transmission while recognising that there would be a continuing challenge for them in meeting some of the restrictions.
"So that's work that we're doing at the moment, and we'll give further advice to Government when we've completed those pieces of guidance".
It comes as there were four more deaths and nine new cases of the virus reported here on Monday.
The Deputy Chief Medical Officer, Dr Ronan Glynn, has warned about rising clusters in the home.
A cluster is defined as three or more confirmed cases in one location within a 72-hour period.
He said: "Last week there were 16 clusters notified in private houses.
"If you or someone in your household experiences ‘flu like symptoms - a cough, temperature, shortness of breath or a change in taste in smell - please do not adopt a wait and see approach: isolate and contact your GP without delay".
COVID-19 Response committee
Meanwhile the Government has been accused of having a blind spot towards small and medium businesses ahead of a meeting of the Special Committee on COVID-19 Response.
TDs will discuss the re-opening of the economy with doctors, business leaders and the Department of Business.
Business group IBEC will call for the immediate removal of quarantine restrictions, for the two metre social distancing rule to be reduced to one metre, and for an extensive track and trace programme.
CEO Danny McCoy will call for certainty as to when restrictions will be lifted, to avoid what he calls 'economic and social destruction.'
The small and medium enterprise group ISME will also criticise the Government in its opening statement to the committee.
CEO Neil McDonnell is expected to tell the committee small and medium businesses are operating in a Government blind spot - and the impression he gets from working with Government agencies is that big business is good, and small business is bad.