Spain has reported the first known monkeypox-related death in Europe of the current outbreak
The country's health ministry confirmed the death on Friday.
Brazil earlier reported the first monkeypox-related death outside the African continent.
In its latest report, the Spanish Health Ministry said 4,298 cases had been confirmed in the country.
Of the 3,750 patients it had information on, it said 120 have been hospitalised - accounting for 3.2% - and one has died, without providing further details.
Latest available data shows the HPSC has been notified of 85 confirmed cases of monkeypox in Ireland.
Earlier this month, the head of the World Health Organisation (WHO) declared the monkeypox outbreak a "global health emergency of international concern".
Dr Tedros Adhanom Ghebreyesus said while the risk globally was "moderate", in Europe it was "high".
The disease can be transmitted from person to person through close physical contact, including sexual intercourse.
It comes as the smallpox vaccine is to be extended for people at high-risk of monkeypox infection in Ireland.
The National Immunisation Advisory Committee (NIAC) has recommended vaccination for gay and bisexual men, as well as other Men who have Sex with Men, and those at high-risk of unprotected exposure.
It says two doses of the smallpox vaccine should be given 28 days apart to as many high-risk individuals "as soon as practicable."
Vaccination against smallpox has been seen to be around 85% effective in preventing monkeypox, the WHO says.
Reporting by: IRN