Only 23 COVID-19 patients are in intensive care tonight - the lowest number since Christmas Eve.
The number has fallen dramatically from a peak of 221 in late January.
There have been no new admissions to ICU in the past 24 hours.
There are 70 COVID-19 patients in Irish hospitals tonight - compared to over 2,000 five months ago.
It was also confirmed today that St James's Hospital in Dublin had no COVID-19 patients for the first time since March 2020.
HSE CEO Paul Reid thanked workers at the hospital for what they've done over the past 15 months.
He said: "They were right in the middle of all of this - they were seeing families coming in together.
"It was very difficult for them to see any light out of this.
"I was very pleased to send our message today, saying really well done and thanks. It's that human piece of it, from a staff and patients perspective."
398 new cases of the virus were reported in Ireland today.
The five-day moving average of new cases has continued to fall in recent days and now stands at 324.