The National Public Health Emergency Team (NPHET) will meet later, as Health Minister Stephen Donnelly has warned the Omicron wave could be worse than the peak of Delta.
Health officials will consider whether more restrictions are needed for over Christmas.
It comes after Tánaiste Leo Varadkar told Newstalk he is expecting NPHET will recommend more measures.
He said they will likely include measures aimed at trying to decrease the amount of social mixing, as well as possible new measures around close contacts and revised rules on international travel.
It is thought travel measures may be relaxed around antigen and PCR tests for incoming passengers.
Minister Donnelly said on Wednesdaya number of modelling scenarios suggested the number of patients in hospital could be as bad or worse than January of this year - but noted that the booster programme will ensure older and vulnerable people have a lot more protection.
"When you are asking me is it potentially similar to last year in terms of the number of cases, yes it could well be," he said.
"It could be more. In terms of hospitalisations, yes that is entirely possible.
"The huge difference to last year is the vaccines and the boosters."
Despite Omicron appearing to be less severe than Delta, it is more infectious and could be the dominant strain here by next week.
Mr Varadkar told his party two million people could have booster shots by the end of the year.
The HSE is finalising a plan to 'really accelerate' the booster campaign, and is aiming to be able to administer 300,000 jabs a week.
Vaccine centre opening times have been extended from 8.00am to 8.00pm, and the 15-minute wait time has been waived to help GPs and pharmacists give more boosters a day.
The plan is expected to see GPs suspending all non-urgent appointments to focus on the booster rollout.
While it is believed the number of jabs that could be administered would double if the 15-minute waiting period is waived.
Additional reporting: Jack Quann
