COVID-19 vaccines can be given at the same time as the seasonal flu jab.
The National Immunisation Advisory Committee (NIAC) has made the recommendation, which has been endorsed by the Interim Chief Medical Officer.
The group has also given the go-ahead for the rollout of a second COVID booster vaccine for those aged 50 to 64.
While a second booster dose will also be offered to those aged 12 to 49 who have an underlying medical condition, or are residents of long-term care facilities.
And a second booster is to be given to pregnant women at 16 weeks or later, who have not already received a booster vaccine in their current pregnancy.
Also as part of the changes, a second booster is to be offered to healthcare workers - and a third booster given to those aged 65 years and older, and those between 12 and 64 who are immunocompromised.
Booster doses should be given four months after a previous COVID vaccine dose or previous natural infection.
Health Minister Stephen Donnelly said: "We have very high protection in the population thanks to our successful vaccine programme.
"The autumn vaccination programme will ensure we continue to protect the most vulnerable in our communities.
"The evidence suggests that a second booster dose may reduce infection rates, which would benefit healthcare workers and help sustain the healthcare system coming into the winter months."
Interim CMO, Professor Breda Smyth, added: "There is clear evidence that the Omicron variant has been less severe than previous variants due to the high uptake of vaccines.
"While we have seen a recent surge in infections, this has thankfully not translated into the same pressure on our hospitals and people getting severely unwell.
"COVID-19 vaccines have been remarkably effective in this regard."