The outgoing Minister for Transport, Tourism and Sport Shane Ross has lost his seat in Dublin Rathdown.
He was excluded on the fifth count in the constituency after Green Party deputy leader Catherine Martin topped the poll.
Speaking on Newstalk, he said that there is now a good chance that the there will be no representatives of the Independent Alliance in the next Dáil.
He said he believes the grouping “achieved a fair amount” during its time in government.
Mr Ross said: "I am feeling a bit uneasy about the situation, it's not looking very good, but that's democracy and I'm happy to accept the verdict of what's happening here."
"There's obviously a rejection of some of the government's policies, which is apparent not only in my own vote but with the votes of many other people.
"I don't think tonight is a time for regret, it's a time to congratulate those who have been successful.
"There has obviously been a huge appetite for change.
"I hope [the elected candidtaes] make a really successful government and bring about the change that is necessary."
— Newstalk (@NewstalkFM) February 9, 2020
Reflecting on his time on government, Mr Ross said: “I am very pleased with the drink driving legislation I introduced.
“It was an extraordinary battle. I was an experiment to get it through the Dáil because initially it did not have the support of all the parties and it was heading for defeat.
“But gradually we got all the parties on side and we introduced life-saving legislation.”
Mr Ross was contesting the three-seat constituency alongside Green Party deputy leader Catherine Martin, Fine Gael Minister Josepha Madigan, and Neale Richmond, also Fine Gael.