The Chief Medical Officer says the COVID-19 pandemic is not over, and there will be an 'ongoing need' for some public health measures.
But Dr Tony Holohan will also tell the Oireachtas Health Committee later the current situation is 'broadly positive'.
He will say it is safe to return to normal activities - such as socialising, exercise, family, work and travel - with cases and hospitalisations falling from the Omicron peak.
Citing a "much improved situation" as a result of vaccination and boosters, Dr Holohan will also say mortality remains relatively stable.
But he will warn that COVID-19 still poses a risk to public health with the need to keep some public health measures - such as masks being worn in all settings where they're currently used, and those with symptoms to immediately self-isolate.
He will also address the issue of anxiety around the recent removal of restrictions, particularly for people who are immuno-compromised.
Dr Holohan will say the risks associated with COVID "are greatly reduced through vaccination" and that people should to go about their daily lives "with appropriate caution".
And he will also say that the global evolution of virus is expected to continue - with Omicron unlikely to be the last variant we will have to face.
Meanwhile there were 10,618 new cases of COVID-19 reported in Ireland on Tuesday.
That breaks down as 4,208 PCR-confirmed cases, as well as 6,410 positive antigen tests registered through the HSE's portal.
And there were 624 patients with COVID-19 in Irish hospitals, with 66 in ICU - both of which had fallen in the last 24 hours.
Additional reporting: Eoghan Murphy