Man Utd are away to Real Sociedad in Group A, knowing a win would virtually guarantee their place in the knockout stages.
Jonny Evans, Rafael and Tom Cleverley all miss tonight's match after suffering knocks in the Premier League victory at Fulham on Saturday.
Premier League rivals Man City are at home to CSKA Moscow in Group D.
A win would put them on the brink of qualifying from their group, as they would move 6 points ahead of CSKA with two games to play.
Joe Hart is set to remain on the bench after being dropped for Saturday's Premier League win over Norwich.
Vincent Kompany and Stevan Jovetic also miss out through injury.