Three goals in 15 second half minutes from Willian, Loic Remy and Kurt Zouma saw Chelsea progress to round 4 of the FA Cup with a 3-0 defeat of Watford.
Second half goals from Ander Herrera and Angel Di Maria saw Manchester United eventually beat League One strugglers Yeovil at Huish Park.
Two goals from James Milner saw Manchester City come from behind to beat Sheffield Wednesday 2-1 at the Etihad.
Stoke were given a scare by Conference side Wrexham, falling behind with 17 minutes to play.
However a goal from Marco Arnautovic and two for Stephen Ireland rescued a 3-1 win for Mark Hughes' side.
A late strike from Christian Benteke gave Aston Villa a 1-0 win at home to Championship strugglers Blackpool.
Elsewhere, Mick McCarthy's Ipswich have forced a replay with Southampton - it finished 1-apiece at St Mary's.
Earlier, QPR became the first Premier League club to lose to lower league opposition in this season's FA Cup, going down 3-0 at home to League One's Sheffield United.
There was no fairytale at the Crabble Athletic Ground, where Crystal Palace beat Dover 4-0. Kevin Doyle rounded off the scoring there.
Sunderland, meanwhile, are safely through to round 4. Patrick Van Aanholt got the game's only goal in a 1-0 defeat of Leeds.
In the evening kick-off, Arsenal took an early lead against Hull thanks to a goal from Per Mertesacker. An 82nd minute goal from Alexis Sanchez was the only other goal at the Emirates, giving Arsenal a 2-0 win.
Final scores:
Dover 0-4 Crystal Palace
Queen's Park Rangers 0-3 Sheffield United
Sunderland 1-0 Leeds United
Aston Villa 1-0 Blackpool
Manchester City 2-1 Sheffield Wednesday
Southampton 1-1 Ipswich Town
Stoke City 3-1 Wrexham
Yeovil Town 0-2 Manchester United
Chelsea 3-0 Watford
Arsenal 2-0 Hull City
Originally posted at 18.05