Leinster say that Sean O'Brien and Cian Healy will not be returning in time for either of their remaining Champions Cup group games.
Both players are following individual training programmes, which had raised hopes that they might be back in time for the final two rounds.
But they are currently slated to resume full contact training in the next two to three weeks.
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Leinster's next European Champions Cup pool game is against Castres on January 17th.
They round off their pool stage commitments at Wasps one week later.