The Health Service Executive (HSE) says there were 100 deaths out of 233 Serious Reportable Events (SREs) in Irish healthcare providers between March 2014 and September 2015.
The findings are included in a report published by the Executive - which found 16 of the deaths involved babies, three happened in a nursing home and 18 related to a fall.
However this does not necessarily mean the death resulted from the incident concerned, as there may have been other factors.
The report follows on from the recent announcement of a patient safety package - including plans to simplify the complaints procedure, enhance the powers of the Ombudsman and HIQA and to reform methods of compensation payments.
The Department of Health Chief Medical Officer, Dr Tony Holohan, said: "The report contains the type of analysis that will add to our patient safety information and intelligence. It will assist us to identify patterns and trends in the occurrence of healthcare incidents".
Patrick Lynch is the national director for quality assurance for the HSE.
He told Newstalk Breakfast that just a small number of cases go wrong each year, but they must be learned from.
"The impact of that can be devastating on individuals and on families - and some of it can be devastating for either the rest of their lives, or for families if they lose a (loved) one it is really significant" he said.
"So we need to be able to first respond with honest and compassion - so be open about it - but the second is we have to learn from it".
"If we don't, the potential is to repeat the same things again" he added.
