Veteran US Senator John McCain has died at the age of 81.
The politician and former presidential candidate had been battling a stage-four brain tumour – and his family announced on Friday that he would no longer continue medical treatment.
The high profile Republican clashed with US President Donald Trump on a range of issues in his latter years.
He lost out to Barack Obama in the 2008 presidential election - but his old rival says despite their differences, they shared "a fidelity to something higher."
Mr McCain was with his wife and family when he died at 4.28pm local time on Saturday, his office said.
He revealed he had been diagnosed with an aggressive form of brain cancer last year.
In a statement on Friday, Mr McCain's family said he had "surpassed expectations for his survival," but the progress of the cancer and his age "render their verdict."
"With his usual strength of will, he has now chosen to discontinue medical treatment," they said.
I love my husband with all of my heart. God bless everyone who has cared for my husband along this journey. pic.twitter.com/v27sEbboii
— Cindy McCain (@cindymccain) August 24, 2018
On Saturday, Cindy McCain thanked well-wishers on Twitter, saying she was "overwhelmed by the outpouring of love and support from around the world."
Following her husband's death, she wrote: "My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years.
"He passed the way he lived, on his own terms, surrounded by the people he loved, in the place he loved best."
The entire McCain family is overwhelmed by the outpouring of love and support from around the world. Thank you.
— Cindy McCain (@cindymccain) August 25, 2018
My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years. He passed the way he lived, on his own terms, surrounded by the people he loved, in the the place he loved best.
— Cindy McCain (@cindymccain) August 26, 2018
Mr McCain was badly injured and spent more than five years as a prisoner of war after his plane was shot down in Vietnam in 1967.
He was elected to the US House of Representatives In 1982 and the US Senate in 1986.
In a statement, Mr McCain's daughter Meghan said her father was a "great fire who burned bright."
"He loved me, and I loved him. He taught me how to live," she said. "His love and his care, ever present, always unfailing, took me from a girl to a woman - and he showed me what it is to be a man."
I love you forever - my beloved father @SenJohnMcCain pic.twitter.com/Y50tVQvlVe
— Meghan McCain (@MeghanMcCain) August 26, 2018
US President Donald Trump paid tribute to the Republican politician on Twitter shortly after his death was announced.
"My deepest sympathies and respect go out to the family of Senator John McCain," he wrote. "Our hearts and prayers are with you!"
My deepest sympathies and respect go out to the family of Senator John McCain. Our hearts and prayers are with you!
— Donald J. Trump (@realDonaldTrump) August 26, 2018
Mr Obama said that despite their differences, he and Mr McCain shared "a fidelity to something higher", citing "the ideals for which generations of Americans and immigrants alike have fought, marched, and sacrificed."
He added: "We saw our political battles, even, as a privilege, something noble, an opportunity to serve as stewards of those high ideals at home, and to advance them around the world.
"We saw this country as a place where anything is possible - and citizenship as our patriotic obligation to ensure it forever remains that way."
Additional reporting IRN ...
