Dr Tony Holohan is to return to his role as Chief Medical Officer next week.
The Department of Health has confirmed he'll be back at his desk from Monday.
Dr Holohan stepped away from the role in July for family reasons.
Deputy chief officer Dr Ronan Glynn has been serving as CMO on an acting basis for the past few months.
Health Minister Stephen Donnelly today said Dr Holohan became a "national hero" during the pandemic.
He said Dr Glynn had done "incredibly well" stepping in over the past few months.
Minister Donnelly said he looks forward to working with both doctors, and that "the more expertise we have" during the winter months the better.
It comes as NPHET meets today to consider the increasing number of coronavirus cases across the country.
The 14-day incidence rate for both Monaghan and Roscommon have jumped to over 100, while Cork and Galway have also been earmarked as areas of concern.
However, Dr Glynn has warned that the 'window of opportunity' is closing for the recent increases to not become a national issue.