Organisers say thousands of people are expected to take to the streets of Dublin in an anti-abortion march later.
The 'Rally for Life' will be the first in-person national pro-life march since 2019.
The organisers claim recent events in the US and elsewhere - such as the overturning of Roe v Wade - have given "fresh momentum" to initiatives.
Spokesperson Niamh Uí Bhríain says the chief aim is to urge the Government to re-think abortion.
"The primary focus of the rally is to hold the Government to account, and to hold the abortion law to account.
"We're saying that the outcomes of the abortion law since 2019 are actually horrific.
"We're seeing a doubling in the number of abortions, something we were told would not happen, we're seeing late-term abortions being carried out".
Rally for Life committee member Megan Ní Scealláin says a review of the current law should be thorough.
"We are calling on the Minister for Health, Stephen Donnelly, to ensure the abortion review is not a whitewash, and that it examines the disturbing outcomes of the abortion legislation.
"Four years after repeal, many voters, including Yes voters, are shocked by the sharp rise in the number of abortions taking place."
TDs including Carol Nolan, Peadar Tóibín and Mattie McGrath will also address the event.
The rally will assemble at Dublin's Parnell Square at 2.00pm and march down O'Connell Street before hearing speeches at Custom House Quay.