The hashtag movement is similar to the #NoMakeUpSelfie which raised millions for cancer research, and the Ice Bucket Challenge, the ubiquitous pale-tipping meme that caught the imagination of the world during the summer.
Several celebrities have already posted their #WakeUpCall, which also asks participants to donate money and nominate three other people to take up the cause.
Stephen Fry and actor Tom Hiddleston both completed the call to action, with Fry tweeting to his 7.5m followers: “I warn you – look away.”
#WAKEUPCALL Text SYRIA to 70007 (to give £5) or http://t.co/xGAxIU755i (I warn you - look away) pic.twitter.com/DoGvA65s1s
— Stephen Fry (@stephenfry) October 6, 2014
#WAKEUPCALL Text SYRIA to 70007 to give £5. http://t.co/Urt3n8y6WE. Nominate @Misskeeleyhawes @EmWatson @josierourke pic.twitter.com/30a8RykcW9
— Tom Hiddleston (@twhiddleston) October 6, 2014
Other stars who have taken part include celebrity chef Nigella Lawson, presenter Claudia Winkleman, and actor Hugh Grant - whose photo was a production still from the movie Cloud Atlas, which sees him needing a lot of beauty sleep.
Text SYRIA to 70007 (& give £5) or http://t.co/JyA7dUL8PN #UNICEF @mariamcerlane @sturdyAlex @lenadunham pic.twitter.com/NovErR2ydx
— Nigella Lawson (@Nigella_Lawson) October 7, 2014
UNICEF #wakeupcall I nominate @AngelaHartnett @clarebalding @bellafreud pic.twitter.com/SmJQVY3NLy
— Claudia Winkleman (@ClaudiaWinkle) October 6, 2014
#WAKEUPCALL I nominate @JohnCleese, @KP24, @JohnBishop. pic.twitter.com/pickqjLFhF
— Hugh Grant (@HackedOffHugh) October 7, 2014
UNICEF ambassador Jemima Khan explained more about the campaign on her Twitter feed: "Post a video of your #WakeUpCall or a photo of yourself first thing.
"Then nominate three friends to show us their #WakeUpCall and help wake people up to the crisis for Syrian children."
She then posted the video of her completing the challenge on her Instagram account:
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#WAKEUPCALL for Syria's 6.5 million children. Text SYRIA to 70007 (to give £5) or www.wakeupcall.org.uk
UNICEF will donate all #WakeUpCall proceeds to its Syria Emergency Fund.
(H/T: Buzzfeed)