Students going to college next month will need a vaccine certificate to access bars and restaurants, but not other areas of the campus.
UCD has announced a return to full-size lectures of up to 500 people for the new academic year.
There will not be a requirement for social distancing in classes but masks will need to be worn in indoor areas.
It is also reducing class times to 45 minutes, while vaccine certs will not be necessary for students attending lectures.
Junior Minister for Higher Education, Niall Collins, told Lunchtime Live while social areas - such as restaurants and pubs - will be under public health guidelines, lecture halls will not.
"Obviously indoors, we're guiding and the principles say that you have to adhere to mask wearing and the normal proper etiquette in terms of public health and hygiene.
"And other facilities around campus - canteens and bars - they operate under the normal public health guidelines that are in force.
"But we're not going to be denying anybody who hasn't taken a vaccine, you're not going to be denied access to your educational facilities".
He says each institution will have its own rules.
"Each college is different, the physical infrastructure is different, the buildings are different, the timetables are different.
"There was general guidance issued, which was approved and vetted by the Chief Medical Officer.
"And our colleges, institutions and further education facilities - they're all autonomous and they run themselves.
"We support them with policy, guidance and with funding and they then have to implement and run their own affairs.
"It really depends on how each individual college will manage their own timetabling, manage the flow of people in and out".
But he believes the majority of those attending college will be vaccinated.
"The cohort of people attending college pretty much are the 18 to 29-year-old cohort, and there's been an exceptionally high uptake of vaccination from that age cohort - which is great.
"By the time college returns in early-middle of September, about 95% of that cohort will be vaccinated."