The Department of Education says schools will close in seven counties on Friday due to Storm Eunice.
Schools will shut in counties which are under either red wind warnings or orange snow warnings.
The affected counties are Cork and Kerry - which are under a status red warning - and Donegal, Mayo, Sligo, Leitrim and Roscommon - which are under an orange snow and wind warning.
The department says schools in other counties can open "subject to local conditions".
However they are being advised to be aware of any change to the status in their county.
"Remote teaching and learning should commence where possible, in line with schools' remote teaching and learning plans", the department says in a statement.
Met Éireann says this is a "multi-hazard event" with wind and heavy snow.
The weather system will bring heavy sleet and snow, leading to blizzard-like conditions in parts, with treacherous driving conditions.
The Department of Education adds that the storm is expected to impact most during school commuting hours, "and this will make journeys to school extremely hazardous in the morning in those areas."
While the Department of Children says early learning and care (ELC) and school-age childcare (SAC) services in those counties - with a status red wind warning or a status orange snow and wind warning - should also not open on Friday.