The Green Party leader says it's "reprehensible" that a protest was held outside Tánaiste Leo Varadkar's house yesterday.
Eamon Ryan said politicians have a right to privacy like everyone else in the State.
Politicians across the political divide have condemned the incident, which saw a small number of protesters gather outside the Tánaiste's home.
A video of the demonstration has circulated on social media, where homophobic language can be heard and anti-vaccine signs can be seen.
Speaking on The Pat Kenny Show, Minister Ryan said "everyone is equal" in a constitutional, democratic republic.
He said: “Those of us in politics… you're not above the law. You've got to make sure you live to the same standards you expect everyone to.
"But it also means you have certain protection - that you’re not targeted in that way, with your house and home and family being put at risk."
In terms of the protest itself, he said: “I think it’s terrible.
"Everyone has the same rights - and that includes the politicians having a right to privacy.
“It’s reprehensible - you shouldn’t be outside someone’s house.”
The Green Party leader said such incidents are "not common", and the gardaí do a good job in responding.
He noted: “My experience is the gardaí are very aware and careful. You have to be careful you don’t ramp it up further."
Minister Ryan suggested politicians in Ireland are "very accessible" to people in Ireland compared to other countries.
Responding to the suggestion that such protests wouldn't be tolerated in the US, he added: "American politics is not in great shape at the moment - would you want to be going down that direction?"