A pharmaceutical firm is to create 200 new jobs in Limerick.
Regeneron says the positions will be in place by the end of 2017, and will be make it the largest capacity biopharmaceutical production facility in Ireland.
These positions are expected to bring its total headcount in Ireland to nearly 550.
The company acquired the former Dell computer facility and got planning approval in April 2014 for its first Industrial Operations and Product Supply (IOPS) site outside of the United States.
With approximately 300 full-time employees, 200 contingent workers and 550 construction workers, recruitment is underway to bring on additional full-time jobs in commercial manufacturing, process sciences, quality assurance/control and various support functions for scientists, chemists and technicians.
Taoiseach Enda Kenny said: "I'm delighted to welcome this exciting additional $350 million investment by Regeneron with 200 additional jobs for Limerick on the same day that the Government is publishing its Mid West Action Plan for Jobs".
"We are intent on keeping this recovery going by keeping Ireland competitive and by attracting more investment and jobs into the regions. Regeneron’s decision to expand so significantly is testament to the talent pool and attractive business environment available to companies in Ireland".
Regeneron's 400,000 square foot IOP facility in Raheen Park will became operational in 2015, and expects to seek licensure for commercial production in 2016.
The company also has a growing team in Dublin supporting its business in Europe.
Dan Van Plew is vice president of Regeneron and says the workforce in Limerick is one of the main attractions for the company.