Marita Moloney
Marita Moloney

09.53 27 Nov 2020


Share this article


A new trial is expected to be run on the Oxford AstraZeneca COVID-19 vaccine after questions were raised about its performance.

The makers are applying for approval for the jab after tests proved it was 70% effective.

That jumped to 90% when an initial half-dose was given, followed by a full dose.

However, US scientists claim the higher rate of effectiveness only occurred in people aged 55 and under, and was discovered by accident.

It follows the announcement of a vaccine trial promising results by Moderna and Pfizer / BioNTech in recent weeks, with trials showing both vaccines to be over 90% effective.

Leading immunologist, Trinity Professor Luke O'Neill, does not believe that the issues over the AstraZeneca vaccine will affect it being approved in Europe.

Speaking on The Pat Kenny Show, he explained that it was a mistake that a lower dose of the vaccine was initially trialled which should make us "slightly concerned".

He said: "As ever, we have to see the data, what's frustrating here with all the trials is that we haven't seen any real data yet.

"This has certainly concerned people, but [AstraZeneca] told the regulator early on about the mistake and the regulator said keep going."

Professor O'Neill added that mistakes do happen in the development of vaccines, it just so happens in this instance that it is is very much "in the spotlight".

He said the good news is that the vaccine is working, and that a new trial is likely to happen soon.

He said: "They will re-run that trial probably now, and they'll do it upfront.

"They'll start with a low dose and then try a high and that can still give a 90% efficacy.

"They've also said it's unlikely to affect approval interests in Europe anyway.

"The FDA are the ones saying we don't like the look of this.

"The European agencies haven't said anything yet but AstraZeneca have said we're still expecting it to go down the approval route but time will tell."

New trial expected on AstraZeneca COVID-19 vaccine after questions raised

00:00:00 / 00:00:00

The Pat Kenny Show

    

Professor O'Neill said AstraZeneca may yet get approval for its two high dose vaccine, which is 62% effective, but the question remains over whether regulators will require the company to do a re-test of its combined low dose and high dose formula.

He added: "The regulators are all over this and examining every bit of data, and now you can imagine the spotlight is on AstraZeneca.

"It will be up to the regulator to decide what to do next with this AstraZeneca trial."

He said he is waiting to see the publication of the data relating to all three vaccines so that "we can have a real go at comparing all three".

Main image: File photo. Picture by: Sean Elias/PA Wire/PA Images

Share this article


Read more about

AstraZeneca Coronavirus Covid-19 Covid-19 Vaccine Luke O'Neill Oxford Vaccine

Most Popular

Live: Title

Now playing

00:00:00 / 00:00:00
Added to queue
Removed from queue

On Air

Share

Share


Up next

Episode title
Show
Duration

You currently have no podcasts in your queue.

Go to podcasts

On Air

The Home Show With Sinead Ryan

The Home Show With Sinead Ryan

09:00-10:00

Share

Up next

DOWN TO BUSINESS WITH BOBBY KE...

DOWN TO BUSINESS WITH BOBBY KERR

10:00-12:00

Share

FUTUREPROOF WITH JONATHAN MCCR...

FUTUREPROOF WITH JONATHAN MCCREA

12:00-13:00

Share

OFF THE BALL

OFF THE BALL

13:00-17:00

Share

TECH TALK WITH JESSICA KELLY

TECH TALK WITH JESSICA KELLY

17:00-18:00

Share

SCREENTIME WITH JOHN FARDY

SCREENTIME WITH JOHN FARDY

18:00-19:00

Share

TED RADIO HOUR

TED RADIO HOUR

19:00-20:00

Share

DOWN TO EARTH WITH CARA AUGUST...

DOWN TO EARTH WITH CARA AUGUSTENBORG

20:00-21:00

Share

DOCUMENTARY AND DRAMA ON NEWST...

DOCUMENTARY AND DRAMA ON NEWSTALK

21:00-22:00

Share

BEST OF THE PAT KENNY SHOW

BEST OF THE PAT KENNY SHOW

22:00-23:00

Share

THE HOME SHOW WITH SINEAD RYAN

THE HOME SHOW WITH SINEAD RYAN

23:00-00:00

Share

BEST OF NEWSTALK

BEST OF NEWSTALK

00:00-07:00

Share

DOCUMENTARY AND DRAMA ON NEWST...

DOCUMENTARY AND DRAMA ON NEWSTALK

07:00-08:00

Share

NEWSTALK BREAKFAST WITH SUSAN...

NEWSTALK BREAKFAST WITH SUSAN KEOGH

08:00-09:00

Share

ALIVE AND KICKING WITH CLARE M...

ALIVE AND KICKING WITH CLARE MCKENNA

09:00-10:00

Share

00:00:00 / 00:00:00

Share on