The mandatory hotel quarantine system has come to an end, after all remaining countries were removed from the list.
Six South American countries were the last nations left on the list, as the system was gradually scaled down.
Over 10,000 people entered mandatory quarantine since it was introduced in March.
Travellers into Ireland must still follow the relevant travel regulations - including the need for a PCR test if they're not vaccinated.
Health Minister Stephen Donnelly said: “The Mandatory Hotel Quarantine system was introduced as an exceptional public health measure at a time that our country was contending with the very serious risk of importation of variants of concern that had the potential to overwhelm our health service and, in particular, to undermine Ireland’s COVID-19 Vaccination programme.
"I would like to take this opportunity to sincerely thank all of those who worked diligently to ensure the system operated smoothly and provided an appropriate level of care to those completing their period of quarantine."
“At the peak of the system’s operation some 60 states were designated and the greatest number of persons in MHQ at one time reached 1,008 on 9 May 2021."
The Government says nearly 3,500 quarantine appeals were lodged, with just over 500 of those granted.
A total of 593 mandatory hotel quarantine residents tested positive for COVID-19.
A number of European countries were on the quarantine list at various points, although calls to add Britain during the summer were rejected.