It's widely speculated that junior minister Lucinda Creighton will have to wave goodbye to the party whip on Wednesday.
The European Affairs minister has given no indication as yet of how she will vote on the Protection of Life During Pregnancy Bill - however it's believed that she may vote against the government.
Minister Creighton has tabled a number of amendments to the legislation - including the removal of the suicide clause.
Political Correspondent with the Irish Daily Star, Catherine Halloran, says she believes the government should have handled the situation differently so as not to lose party members:
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