Members of the public will be able to use an online portal to register for vaccine appointments for the first time on Thursday.
Those aged 69 are being asked to register when the system goes live at 10.00am.
While those aged between 65 and 68 are being asked to register each day over the following number of days.
Over the coming weeks, about 180,000 people will be asked to register for vaccination.
People will be vaccinated at one of the HSE vaccination centres around the country.
However, those who have an appointment for vaccination already don't need to register.
For others, here is what you need to do. You can register by phone at 1850-24-1850 or online at www.hse.ie.
Those registering online will need:
- Their PPS number
- A mobile phone number
- An e-mail address
Once a person has registered, they will receive appointment details by text message between three to seven days before their vaccination is due to take place.
People are being asked to register on specific days to help manage demand.
If you are aged:
- 69 register on Thursday 15th April, or any time after
- 68 register on Friday 16th April, or any time after
- 67 register on Saturday 17th April, or any time after
- 66 register on Sunday 18th April, or any time after
- 65 register on Monday 19th April, or any time after
But the Health Service Executive (HSE) says there is "no hurry to register immediately" - as registering first does not mean a person will get vaccinated first.
The AstraZenca vaccine is expected to be used with these appointments.