There have been 2,098 further cases of COVID-19 in Ireland - the highest in a single day since January 22nd.
The latest available figures show 251 patients are hospitalised with the virus - 52 of which are in ICU.
The five-day moving average of COVID-19 cases has risen to 1,766.
Chief Medical Officer, Dr Tony Holohan, says the high numbers are concerning.
"For the second time in a week, we are reporting over 2,000 cases.
"We haven't seen this number of cases since late January 2021. This is a concerning indication of the level of COVID-19 circulating in our communities.
"COVID-19 vaccines are very effective against severe illness from COVID-19, and are protecting people from needing care in hospital and ICU.
"While it is possible for fully vaccinated individuals to become infected with COVID-19 and pass the virus on to others, vaccines also remain effective in significantly reducing this risk.
"That is why it is vital for as many people as possible to come forward for vaccination against this disease.
"We must all remain vigilant to the risk of contracting COVID-19.
"To protect everyone and to safeguard the progress we have made, please follow the public health advice to limit transmission of COVID-19."
He adds: "If you display symptoms of COVID-19 like cough, fever, headache, sore throat and blocked or runny nose - isolate and get a test immediately.
"Continue to socialise safely by risk assessing, meeting outdoors where possible. Only meet up with small numbers of people and avoid crowds. Remember, it is OK to leave if you do not feel safe."
It comes as walk-in vaccine centres will offer second dose vaccines this weekend.
So far, the walk-in centres had been limited to just first doses.
However, a number of dedicated second dose walk-in clinics are opening across the country.
They will be open for people who received their first dose of a Pfizer vaccine at least 21 days ago - or anyone who received their first Moderna jab at least 28 days ago.
There are a smaller number of Moderna vaccination clinics, with most sites only offering second dose Pfizer vaccines.