Taoiseach Enda Kenny will meet German Chancellor Angela Merkel in Berlin today to discuss the fallout from Brexit.
Mr Kenny is expected to highlight concerns about North-South relations, the common travel area and Irish trade with the UK.
A spokesperson said he will also “reiterate Ireland's own commitment to EU membership”, and “call for a calm and measured approach to the negotiations with the UK”.
Speaking before his departure, Mr Kenny said: “In Ireland, we very much see our future at the heart of Europe and this view is supported by the vast majority of the population.”
The two leaders will discuss the future direction of Europe, with the Taoiseach likely to push for progress on issues such as investment, the single market, the digital single market and counter-terrorism.
Theresa May, who succeeds British PM David Cameron on Wednesday, yesterday ruled out holding a second EU referendum
The incoming Tory leader, who backed staying in the bloc, said: "Brexit means Brexit and we will make a success of it."