Manchester United may have to face Bayer Leverkusen without England pair Danny Welbeck and Phil Jones.
Welbeck has a knee injury while Jones has an ankle injury.
Wayne Rooney is expected to start and will once again wear his protective head gear.
Read a tactical analysis of the game here.
Crosstown rivals Manchester City travel to the Czech Republic to face Viktoria Plzen.
Captain Vincent Kompany took a full part in training yesterday so he may be available for the game.
Meanwhile, Chelsea have confirmed that Frank Lampard and Oscar will start for in tomorrow's meeting with Basle at Stamford Bridge.
But Juan Obi Mikel may miss the game. This morning he trained with heavy strapping on his knee after picking up an injury against Everton on Saturday.
Celtic are also in action tomorrow and will be without James Forrest for their clash with AC Milan.
He has not travelled due to illness and injury.
But Joe Ledley and Adam Matthews have joined the squad heading to Italy despite carrying knocks.