Shamrock Rovers will begin the defence of their SSE Airtricity League Premier Division title at home to Dublin neighbours UCD.
The Extra.ie FAI Cup Champions St. Pat's will also get the 2022 season underway with a Dublin derby, they're away to newly-promoted Shelbourne as Damien Duff settles into life at Tolka Park.
Elsewhere, Stephen O'Donnell and Dundalk will welcome Derry City to Oriel Park in the first round.
While Finn Harps are set to host Drogheda United and Sligo Rovers will welcome Bohemians to the Showgrounds.
The season will kick-off on Friday, February 18 with four rounds of fixtures across a 36-game calendar that will conclude on Friday, November 4.
The first league meeting of Shamrock Rovers and Bohemians will be on March 11 at Tallaght Stadium.
Fixtures | SSE Airtricity 2022 Premier Division
▪️ Season set to begin Friday, February 18
▪️ Conclude on Friday, November 4
▪️ No fixtures during international windows
— SSE Airtricity League (@SSEAirtricityLg) December 20, 2021
Looking ahead to the upcoming season, SSE Airtricity League Director Mark Scanlon said;
“The publication of the fixture list marks the start of the new season for many fans. We have already seen very impressive season ticket sales across many of our clubs and we look forward to a competitive and compelling Premier Division in 2022.
“Recognising the expanding UEFA club competition calendar, the growing presence of international footballers in our League now and this being a FIFA World Cup year, we sat down with the clubs, managers, players, PFA Ireland and our own National League committee before finalising this schedule.
“I wish all our clubs well for the new season and would again like to thank SSE Airtricity for their continuing support of the League of Ireland as we look ahead with great anticipation to the 2022 campaign.”