Leaders Manchester United are among the sides involved in today's 3pm matches as they host Norwich at Old Trafford.
The Canaries defeated Alex Ferguson's men at Carrow Road earlier in the season with Anthony Pilkington finding the net with his head.
Everton will also be hoping to get their European ambitions back on-track as they entertain Reading at Goodison Park.
Chelsea manager Rafa Benitez will be hoping that his plea for support from the fans will result in a better performance as they host West Brom.
The Blues boss has urged the club's fans to stop campaigning against him because its damaging for the team:
In the other 3pm games, Southampton host QPR at St Marys as the Saints look to stretch their points gap from the drop zone while QPR hope to get nearer to clambering out; West Ham travel to Stoke while Fulham are away to Sunderland and Swansea entertain Newcastle.
The late game this evening is at the DW Stadium where Wigan will entertain Liverpool from 5.30pm with the Latics back in form after a 3 - 0 win over Reading last weekend.