Goals from Daniel Sturridge and Adam Lallana saw Liverpool come from behind to beat Crystal Palace 2-1 at Selhurst Park, and in the process book their place in the FA Cup sixth round.
For the second consecutive round in this season's FA Cup, Blackburn claimed a Premier League scalp at Ewood Park.
Josh King scored a hat-trick in a 4-1 defeat of Stoke. Mark Hughes' side also had Geoff Cameron sent off just before half time.
32-year old Yakubu, meanwhile, got the winner for Reading, who were 2-1 victors away to Derby.
Earlier, West Brom breezed into the sixth round, with a 4-0 pasting of West Ham at the Hawthorns.
Brown Ideye struck twice, and West Ham had substitute Morgan Amalfitano sent off there.
Full-time scores:
West Brom 4-0 West Ham
(WB: Ideye 20', Morrison 42', Ideye 57', Berahino 72')
Blackburn 4-1 Stoke
(B: King 36', 50', 55', Gestede 45 + 6'// S: Crouch 10')
Derby 1-2 Reading
(D: Bent 61' // R: Robson-Kanu 53', Yakubu 82')
Crystal Palace 1-2 Liverpool
(CP: Campbell 15' // L: Sturridge 49', Lallana 58')