Paul O'Connell has recovered from the chest infection that prevented him from lining out against Scotland in the Six Nations opener.
The Munster second row is now available to lead Ireland against Wales on Saturday at the Aviva Stadium.
The only other change to the side that started against the Scots sees Gordon D'Arcy replace Luke Marshall at inside centre.
D'Arcy will partner Brian O'Driscoll in the Irish midfield for the 53rd time with Conor Murray and Johnny Sexton named as the half-back pairing.
The back three that provided two of Ireland's tries against Scotland is retained with Rob Kearney at fullback and Dave Kearney and Andrew Trimble on the wings.
Image by ©INPHO/Billy Stickland