Aston Villa's shock exit from the fourth round of the FA Cup last night at the hands of Millwall will serve a warning to the rest of the Premier League clubs on Cup duty this afternoon.
The opening game of the day is at the Britannia Stadium, as Stoke play host to league champions Manchester City City.
The Potters will be looking for revenge for their 2011 Cup final defeat.
Tony Pulis' men are are starting their first home game in the FA Cup for the past eight outings, with kick-off at 12:45pm.
Upset
In the afternoon matches, Everton and Arsenal will be among the sides hoping to avoid an upset.
Seamus Coleman and Darron Gibson are both doubtful for the Toffees as they visit the Reebok Stadium to face Bolton, while Arsenal are away to an in-form Brighton side that beat Newcastle in the last round.
Wigan, Norwich, QPR and Reading are also involved in the three o'clock matches.
Wigan are away to Macclesfield while Norwich host Luton.
QPR and Reading also have home advantage against the MK Dons and Sheffield United.
The late match this evening is at Old Trafford as Manchester United host Fulham at 5.30pm.
