Leinster say that they do not expect Gordon D'Arcy to be available for their season finale against Edinburgh.
The centre, who will retire from rugby after the World Cup, and his wife are expecting their first child this week.
The Ireland international featured against Treviso on Friday in what may well be his final appearance for the province.
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Meanwhile, winger Darragh Fanning has also been ruled out of the trip to Murrayfield after being told that he will require surgery on a wrist injury.