Here are the main developments following the suspected suicide bombing attack at an Ariana Grande concert at the Manchester Arena:

• Twenty-two people have been killed and 59 people injured. Children were among the dead.
• Police say a lone male suicide bomber detonated an improvised explosive device in the terrorist attack.
• Police say they are trying to establish whether the dead attacker was working alone or as part of a network.
• The bomber was carrying a rucksack, according to Sky sources.
• Police are working with counterterrorism officers and intelligence services to find out more about the attacker.
• Police were called at 10.33pm to reports of an explosion at the end of an Ariana Grande concert.
• Victims described being thrown by the blast that scattered nuts and bolts across the floor.
• The gig was sold out, and thousands of children and teenagers were in attendance.
• Sixty ambulances attended the incident, and the wounded were taken to eight hospitals around Greater Manchester.
• Ariana Grande has tweeted: "broken. from the bottom of my heart, i am so so sorry. i don't have words."
• The singer's management team, Scooter Braun Projects, said: "Words cannot express our sorrow for the victims and families harmed in this senseless attack. We mourn the lives of children and loved ones taken by this cowardly act."
• Home Secretary Amber Rudd has said the explosion was a "barbaric attack deliberately targeting some of the most vulnerable in our society".
• Theresa May has condemned the "appalling incident". The Prime Minister will chair a meeting of the Government's emergency COBRA committee later.
• General Election campaigning has been suspended.
• A large cordon remains in place around Manchester Arena and Victoria Train Station, which backs on to the area.
• All trains and trams to the station have been cancelled.
• The Manchester Arena is the largest indoor arena in Europe, and has a capacity of 21,000.
• It is the worst attack in the UK since 56 people were killed in the 7/7 London bombings in 2005.
• People concerned about loved ones can call +44 161 856 9400. To report any concerns about terrorism, call the anti-terrorist hotline on +44 800 789 321.
• Anyone with concerns for Irish citizens in Manchester can contact the Irish embassy in London: +44 207 2358 2171 or 01 408 2000.
• Greater Manchester Police says anyone who needs help or assistance in Manchester following last night's incident should go to Gate 11 of the Etihad Stadium.