The Taoiseach will touch down in Japan today as part of a four-day official visit.
Michael Martin will also travel to Singapore during the tour of the Asia-Pacific region.
The visit to Japan is the first by a Taoiseach since 2013 and is aimed at strengthening Irish/Japanese relations.
Mr Martin is due to meet with political representatives, the business community and members of the Irish diaspora.
He will also meet with Japanese Prime Minister Fumio Kishida tomorrow, where he will express condolences on the killing of former Prime Minister Shinzo Abe.
Really looking forward to my visit to Japan and Singapore – two nations with which we in Ireland have much in common.🇯🇵🇸🇬🇮🇪https://t.co/k6kcNA10zp@IrishEmbJapan @IrlEmbSingapore pic.twitter.com/ol5cgZW3B4
— Micheál Martin (@MichealMartinTD) July 19, 2022
The Taoiseach will also discuss Russia's invasion of Ukraine, restoring supply chains and maintaining economic growth.
In a statement, Mr Martin said he was “greatly looking forward” to the visit.
“These are two nations with which we in Ireland have much in common,” he said.
“While there, I expect to discuss Russia’s immoral and inhumane invasion of Ukraine, the impact of which is being felt all around the world.
“We’ll also discuss global challenges, maintaining economic growth, restoring broken supply chains, and how we can work together on climate change.
“Our Global Ireland Asia Pacific Strategy seeks to deepen our links across the region, and this trip will be an opportunity to create even more opportunities for our countries to work together.”
On Thursday, the Taoiseach will fly to Singapore where he'll meet Prime Minister Lee Hsien Loong.
The visit will be the first by a Taoiseach there since 2004.
Before travelling home late on Friday, he'll meet with Irish companies operating in the country, engage with the Irish community and visit Changi Chapel and Museum.
Additional reporting Michael Staines.