There are currently 59 patients being treated in hospital for COVID-19, the lowest level in nearly nine months.
The number of people in intensive care with the virus now stands at 23, which is also the lowest this year.
More than 2,000 people were in Irish hospitals five months ago with coronavirus.
The CEO of the HSE Paul Reid said the number of COVID-19 inpatients in hospitals continues "an amazing decline".
"Down to 59 cases with 23 of those in ICU. This is a remarkable benefit of our strong vaccination programme and public support overall," he said.
"We all deserve to cherish and protect these great moments."
He also thanked workers at St James's Hospital in Dublin for their work over the past 15 months.
The facility confirmed yesterday that it had no COVID-19 patients for the first time since March 2020.
It comes as 398 new cases of the virus were reported in Ireland yesterday.
Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin, reiterated Mr Reid's comments and said the drop in hospital numbers is due to vaccination.
"Right now, the numbers in hospital are dropping significantly and that's very good news," he said.
"That's probably because most of the cases are in the younger population which don't get as severe disease as the older population.
"So that's a direct result of the benefits of vaccination in the older population."
