New figures show there has been a 68% reduction in fatalities on Irish roads since 1998.
This was the year of the first Government Road Safety Strategy.
In 1998, 458 deaths occurred on Irish roads, compared with 146 in 2018.
The finding was made on Thursday at the Road Safety Authority's annual International Road Safety Conference.
This will also inform the development of the next road safety strategy, which will run from 2021 to 2030.
The strategy is expected to address current and new road safety challenges - including the impact of new technology, vulnerable road users, serious injuries and killer behaviours.
Transport Minister Shane Ross told the conference: "The development of a new road safety strategy will require considerable engagement with stakeholders at national, regional and local level.
"The development of the new strategy will also crucially involve analysis of international experience and best practice.
"That is why I am glad to see this process is well under way with today's conference and the examination of important insights from leading road safety experts."
While Liz O'Donnell, chairperson of the RSA, added: "The next national road safety strategy will have new elements to take account of a changing society, environment and life styles.
"Technology will transform our capabilities. The climate change agenda too will influence our endeavours.
"How citizens want to live their lives too; and a huge interest in healthy cities and public transportation modes must be accommodated.
"Cycling and walking must ascend the pecking order in terms of priority."