The HSE says 70% girls are now getting the HPV vaccine.
It's a 20% rise in the uptake rate of the vaccine in just over two years.
Health officials say the increase in girls getting the jab - which helps protect against cervical cancer - is "extremely encouraging".
Dr Lucy Jessop, head of the HSE's National Immunisation Office, observed: "The World Health Organization has remarked on Ireland’s achievements and I urge all parents to ensure they get the vaccine which is safe and effective.”
“It has been well articulated in recent months that eliminating cervical cancer is now an achievable goal, nationally and internationally.
"If we continue on this path and continue to increase our uptake rates, we can look forward to future generations living in a world where this cancer is eradicated.”
Dr Jessop also praised HPV vaccine advocate Laura Brennan.
She said the 26-year-old's "intelligence, determination and fearless advocacy" has helped influence parents to vaccinate their daughters.
Laura herself said she's "thrilled that people are listening".
— HSE Ireland (@HSELive) March 11, 2019
Health Minister Simon Harris added: "Despite significant challenges including the spread of dangerous anti-vaccination myths, these figures show women are continuing to get vaccinated.
"As Laura has strongly articulated, vaccination saves lives."
Vaccination teams will be going into secondary schools across the country this week so girls can get the second dose.