The move comes amid a public anger and allegations of tax avoidance in the UK
Facebook will no longer route sales for its largest advertisers through Ireland after a total overhaul of its tax structure, according to reports from the BBC.
This would result in the US firm paying more tax in other territories, including the UK.
Smaller business sales will still be routed through the Dublin office, which will remain the company's international headquarters.
Facebook will not longer book sales to major companies including Unilever, Tesco, Sainsbury and major advertising houses like WPP in Ireland.
These changes will come into effect in April - the first tax bill will be paid in 2017.
Facebook was heavily criticised when it was revealed that it paid only £4,327 in corporation tax in the UK during 2014 - despite the fact that Britain is its second largest market.
"On Monday, we will start notifying large UK customers that from the start of April, they will receive invoices from Facebook UK and not Facebook Ireland," an internal post, seen by the BBC says.