Its clearance height is to increase to 5.03 metres
Irish Rail is to replace the most struck railway bridge in the country.
The bridge at Carrick-on-Suir has been struck 41 times since 2009.
Currently the bridge is a traditional beam and steel construct, which was built in 1931. It was fitted with collision protection beams in 2007.
The current clearance height is 4.54 metres and this will increase to 5.03 metres with the installation of the new bridge.
The new structure was designed by the Iarnród Éireann assisted by the design and production teams in concrete specialists Shay Murtagh Precast.
It will have a reinforced concrete deck with an embedded rail system to reduce the construction height.
The track will be raised over 150 metres on the approach to the bridge to facilitate the increased clearance.
The bridge will be lifted in one movement over the weekend using a 500 tonne crane.
The Pill Road (N24) at Carrick-on-Suir will be closed from 8.00pm on February 22nd until 8.00am on February 27th.
A traffic management system will be in place while train services will be substituted with a bus transfer between Limerick Junction and Waterford.
The number of Bridge strikes on the Iarnród Éireann network reached 95 in 2016.
It says hitting of Bridges by large vehicles is one of the greatest safety risks, and that the company works closely with the Road Safety Authority and Haulier stakeholders to raise awareness of the problem.