More than 40 walk-in COVID-19 vaccination centres are set to open across the weekend.
This follows a successful run during the bank holiday weekend, which saw over 30,000 people receive a vaccine.
The HSE's chief clinical officer, Dr Colm Henry, had indicated the centres would re-open based on the uptake.
"One of the objectives of the walk-ins was to try and see whether we could attract people as well who, perhaps previously, hadn't engaged with the programme and weren't registered", he said.
"And we found good uptake - indicative numbers would suggest that nearly as close as half the people who attended the walk-in clinics over the weekend were people who hadn't previously registered."
They will be open to anyone who is set to receive their first dose of Pfizer who is aged 16 and over.
Those who already have an appointment booked can also use the walk-in facilities.
They will need to bring a photo ID that shows their date of birth.
While those who have not already registered online will need a PPS number, Eircode, mobile phone number, e-mail address and a photo ID.
The walk-in vaccine centres were hugely successful last weekend, so we're doing them again this weekend (for anyone age16+). Locations for the next few days, plus opening times and what you need to bring are right here. pic.twitter.com/x83MPraJO9
— Stephen Donnelly (@DonnellyStephen) August 5, 2021
The head of the HSE, Paul Reid, says officials feel there is still more "potential" to vaccinate people through walk-in centres.
He says this would have covered most of the people who would have wanted to use the facilities.
But it is hoped there will be strong uptake again this weekend.
"We do feel that there's still a further potential in walk-in facility process.
"Therefore we will be running these again this coming week - the three days over the weekend.
"We do feel that last weekend we will have captured probably most of this opportunity that there is there.
"But we once again open the facility to see if there are some further people that we can cover and capture through this process once again".