294 children went missing from State care last year.
According to Freedom of Information figures released to Newstalk, the majority were teenage boys.
Tusla says children reported missing from care are recognised as the most vulnerable in society.
The Gardaí are notified and they help to find them.
These new figures show the number of cases in which children went missing from State care last year.
There were 319 cases involving 294 individual children.
They were all aged between 10 and 17.
John Church is the chief executive of the ISPCC.
He says it is especially worrying when children in State care go missing.
"Most 11 to 17-year-olds in any family environment are out on their own... or there's a period between school and coming home or whatever," he said.
"But these children would probably be more at risk, so they will be of higher concern to us and the public in general.
"It is a time when - for the ISPCC - if we're called into situations like this, we would treat them with great concern," he added.
Tusla says these incidents relate to children going missing for a period of 20 minutes or more.
The agency says most of the children were found within 24 hours, and all were eventually located.