He'll take to the stage at the London venue on the 11th of July, after his plans to play in Hyde Park this summer fell through.
Wembley stadium can fit 90,000 people at full capacity.
The rapper announced the news on BBC Radio 1 yesterday. He said: "I know Wembley Stadium's huge."
He also said that, at the moment, he would rather do big one-off concerts than lengthy tours: "I'm not saying I'll never be ready for that again, but right now, this is what's working for me."
Eminem last played in Ireland at Slane Castle in August 2013 and there have been no announcements of a concert here so far in his 2014 lineup.