Supporters of deposed Egyptian President Mohamed Morsi have clashed with police as they continue to demand his return to office.
Police fired tear gas at protesters near Ramses Square in central Cairo.
Demonstrators retaliated by throwing rocks back at police - many protesters were injured.
Thousands also staged a sit-in near the Rabia el Adawiya mosque to protest Mr Morsi's ousting by the military.
Marches by Morsi's supporters have been largely peaceful since violence peaked a week ago, when more than 50 Muslim Brotherhood supporters were killed in clashes with the military.
Deputy president of the Brotherhood's political party, Essam el Erian, stressed the rallies should remain peaceful.
"The fact that our protests are peaceful is what makes them powerful," he said.
US signals
The clashes came as the US Under Secretary of State, Bill Burns, held talks in Cairo with Egypt's interim president, Adli Mansour, about the transition plan put forward by the new leadership.
The road map calls for the amending of the Islamist-drafted constitution, approved in a referendum under Morsi, and then parliamentary and presidential elections early next year.
Mr Burns said Washington is committed to helping the Arab country succeed in its "second chance" at democracy, but he said it would only happen with the participation of the Muslim Brotherhood.
But his remarks signalled that Washington, while calling for an inclusive transition, is moving on from Morsi and his Brotherhood group.