Some 300 new jobs are to be created in Limerick by US biotechnology company Regeneron Pharmaceuticals.
The jobs form part of a $100 million (€85m) expansion plan for the company's campus in Raheen.
Regeneron develops medicines to help patients with cancer, eye disease, heart disease and a range of other illnesses & conditions.
Recruitment is ongoing for the new positions, and the company expects to employ over 800 people in Ireland by the end of next year.
The jobs are said to be across commercial manufacturing, process sciences, quality assurance/control/validation and various support functions.
Welcoming the announcement, Tánaiste Frances Fitzgerald said: "Regeneron, a leader in the global biopharma industry, set up in Limerick in 2014 and has created a world-class science hub to produce medicine for millions of people.
"I am delighted to see the great progress made to date giving rise to further substantial investment and additional jobs to be created in Limerick. It is great news for Limerick and the wider region."
Dan Van Plew, Executive Vice President and General Manager of Industrial Operations and Product Supply (IOPS) at Regeneron, explained the company chose to locate in Limerick in 2013 because they "simply felt good" about the people, community and universities.
He observed: "A few years and a lot of experience later, I can now confidently say I know Limerick is a place where you can build and thrive as a biotech. We are proud of what has happened here and the vast majority of this work has been completed by people who come from Munster.
"These folks built, validated and began production in a way I'd put up against any other team on the planet. We feel at home here and the way we have been welcomed has made our ongoing growth and investment in Limerick rewarding on the most personal levels."