It is thought the plane was from Mexican carrier Damojh
A plane has crashed at Cuba's José Martí Intentional Airport in Havana, with state media reporting more than 100 people have died.
It happened on Friday morning local time as the plane was on take-off from the Cuban capital.
Reports claim three survivors were found earlier in a critical condition and taken to hospital.
However one of the survivors is understood to have since died.
The Boeing 737 came down with 104 passengers and nine crew on board.
The Department of Foreign Affairs says it has not had any reports of any Irish citizens caught up in the incident.
"However, we stand ready to provide consular assistance if necessary", a statement adds.
An intense column of smoke was seen near the airport after the crash.
Police, fire and medical emergency services were sent to the scene.
The internal flight was bound for Holguin, in the east of the country.
Cuban President Miguel Díaz-Canel has visited the crash site, along with the health minister and other officials.
The director of Cuba's Air Transport, Mercedes Vázquez, has been quoted as saying the plane was from the Mexican airline, Damojh.
Flight tracking websites indicated the flight was CU972, possibly leased from the Mexican carrier.
Anyone with concerns for Irish citizens can contact the Department of Foreign Affairs in Dublin on +353-1-408-2000