The singer was forced to stop and restart a cover of Fastlove
Adele has won best album, record and song of the year at the star-studded Grammy music awards show in Los Angeles.
The British singer's hit track Hello has beat Beyonce's Formation at the 59th annual ceremony, which saw the singer take home five awards after delivering a stirring tribute to George Michael.
The 28-year-old star was forced to stop and restart a cover of Fastlove, apologising to the audience for the pressure of honouring the late singer.
"I f**** up," she said, "I can't mess this up for him".
In her acceptance speech, Adele apologised for swearing, adding Michael meant so much to her that she didn't want to slight him with a poor performance.
She also took home best pop vocal album for 25 and best pop solo performance for Hello.
The singer becomes the second woman to win album of the year twice after Taylor Swift broke the record last year.
"I can't possibly accept this award," she said.
"I'm very humble and I'm grateful and gracious but the artist of my life is Beyonce and the Lemonade album was just so monumental - Beyonce, it was so monumental," Adele added.
"We got to see another side to you that we don't always see. We appreciate that. All us artists here, we f****** adore you."
Although overshadowed by Adele, Beyonce did not leave empty handed.
On her first public performance since announcing her pregnancy, she took home best urban contemporary album for Lemonade and best music video for Formation.
On stage, Beyonce said the album was made to "give a voice to our pain" and to "confront issues that make us uncomfortable".
The singer also performed two songs from her hit visual album, as husband Jay Z and daughter Blue Ivy cheered from the audience.
Absent from both the stage and the public were music superstars Justin Bieber, Kanye West and Drake.
The later won best rap performance and best rap song for Hotline Bling - Drizzy's hit single from his fourth studio album Views.
But the brightest rap star of the evening was Chance The Rapper, taking home the first award in the live telecast for best new artist.
He also bested Drake and West for best rap album - the first streaming-only album to do so - and best rap performance.
"I didn't think we were gonna get this one," he said.
The late George Michael was not the only singer being honoured though, with Bruno Mars rocking a glittery tribute to Prince, covering the icon's Let's Go Crazy hit.
"Make some noise for Prince y'all," Mars yelled to a raving audience.
David Bowie, who died last year from cancer, won all four awards he was nominated for, including best rock song for Blackstar.
James Corden, who hosted the Grammys for the first time, rapped some of his monologue at the top of the show, namedropping Prince, Rihanna and Drake.
More than 13,000 music professionals in the Recording Academy voted to determine winners of the Grammys on Sunday, with other key winners including Sturgill Simpson's A Sailor's Guide To Earth for best country album and Cage The Elephant's Tell Me I'm Pretty for best rock album.