The woman was seriously injured when the car she was driving collided with another car.
She was taken by ambulance to Wexford General Hospital but was pronounced dead a short time later.
The male driver and female passenger in the other car, both in their 50’s were seriously injured and taken to Wexford General Hospital.
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The road was closed to facilitate a Garda Forensic Collision Examination but has since reopened.
Gardaí are appealing for witnesses to this collision to contact them at Wexford Garda Station on 053-916 5200, The Garda Confidential Line 1800 666111 or any Garda Station.