A two-week voluntary redundancy application period has begun for staff at the charity
Aid agency Goal says up to 25 jobs could go at its head offices in Dublin and London as it deals with 'tighter funding'.
Late last year, the Irish Government released payments of almost €4 million in funding to the charity.
The funding had been withheld earlier in the year due to an ongoing US investigation of a number of NGOs over the procurement of humanitarian supplies for victims of the crisis in Syria.
Amid the investigation, Barry Andrews stepped down as CEO of the charity.
The charity is now implementing an action plan to "further enhance its governance and control processes".
In a statement today, the aid agency says they are hoping to mitigate the impact on its humanitarian relief efforts.
They say a two-week voluntary redundancy application period has been opened for all staff in a bid to avoid compulsory redundancies.
Potential redundancies would take place around the beginning of March this year.
Celine Fitzgerald, General Manager with Goal, said: “2016 was a challenging year for GOAL as we sought to continue our relief efforts whilst also taking significant steps to restore the confidence of our donors in our systems, controls and management capacity.
"The last number of weeks have seen substantive progress in that regard with Irish Aid taking the welcome decision to resume payments to GOAL of almost €4 million in funds due for 2016, and USAID recently approving the awarding of a grant to GOAL for our programmes in Honduras, Ethiopia and Sudan."
However, she added that problems remain despite the progress made and discussions with major donors over future funding.
"We need to develop a more sustainable cost base to support our ongoing humanitarian relief efforts and regrettably, this is likely to involve some redundancies,” Ms Fitzgerald said.