The Jack Russell Terrier type dogs are being cared for at the National Animal Centre in Longford
The ISPCA has issued an appeal for new homes for 28 dogs & puppies.
The charity says it received a call expressing concerns for the Jack Russell Terrier type dogs.
Inspectors attended a property and found that the dogs had been allowed to breed freely, while several of the dogs are said to have been 'spiralling out of control'.
The dogs include 17 puppies, and the majority are under 18 months of age.
The ISPCA is caring for the dogs at the National Animal Centre in Longford, and the charity says the animals appear to be in good health.
Chief Inspector Conor Dowling said: “While we are pleased to have been able to intervene before any major welfare issues arose, spaying or neutering would have prevented these unwanted litters of puppies from being born in the first place.
"The rescue and rehabilitation of such a large number of dogs and puppies places a significant amount of pressure on the ISPCA, both financially and also in terms of accommodating such an influx of animals."
Mr Dowling added that Ireland has a "serious problem" with stray and unwanted dogs, and called on dog owners to have their pets neutered or spayed.
Anyone looking for information about the dogs can visit the ISPCA website, email firstname.lastname@example.org, or call (043) 33 25035 (0).